Search results for: Francesco Cappelli

Items from 1 to 20 out of 48 results

article

Diagnostic pathways to wild‐type transthyretin amyloid cardiomyopathy: a multicentre network study

Giacomo Tini, Paolo Milani, Mattia Zampieri, Angelo G. Caponetti, more

European Journal of Heart Failure > 25 > 6 > 845 - 853

Aim Epidemiology of wild‐type transthyretin cardiac amyloidosis (ATTRwt‐CA) remains poorly defined. A better characterization of pathways leading to ATTRwt‐CA diagnosis is of key importance, and potentially informative of disease course and prognosis. The aim of this study was to describe the characteristics of contemporary pathways leading to ATTRwt‐CA diagnosis, and their potential association...

article

Terahertz Sources Based on Metrological‐Grade Frequency Combs

Elisa Riccardi, Valentino Pistore, Luigi Consolino, Alessia Sorgi, more

Laser & Photonics Reviews > 17 > 2 > n/a - n/a

Broadband metrological‐grade frequency comb (FC) synthesizers with a rich number of phase locked modes are the ideal sources for quantum sensing and quantum metrology. At terahertz (THz) frequencies, electrically pumped quantum cascade lasers (QCLs) have shown quantum‐limited frequency noise operation, phase/frequency absolute referencing and self‐starting FC operation, albeit over a rather restricted...

article

Unmasking the prevalence of amyloid cardiomyopathy in the real world: results from Phase 2 of the AC‐TIVE study, an Italian nationwide survey

Marco Merlo, Linda Pagura, Aldostefano Porcari, Matteo Cameli, more

European Journal of Heart Failure > 24 > 8 > 1377 - 1386

Aim To investigate the prevalence of amyloid cardiomyopathy (AC) and the diagnostic accuracy of echocardiographic red flags of AC among consecutive adult patients undergoing transthoracic echocardiogram for reason other than AC in 13 Italian institutions. Methods and results This is an Italian prospective multicentre study, involving a clinical and instrumental work‐up to assess AC prevalence among...

article

Incidence and risk factors for pacemaker implantation in light‐chain and transthyretin cardiac amyloidosis

Aldostefano Porcari, Maddalena Rossi, Francesco Cappelli, Marco Canepa, more

European Journal of Heart Failure > 24 > 7 > 1227 - 1236

Aims The incidence and risk factors of pacemaker (PM) implantation in patients with cardiac amyloidosis (CA) are largely unexplored. We sought to characterize the trends in the incidence of permanent PM and to identify baseline predictors of future PM implantation in light‐chain (AL) and transthyretin (ATTR) CA. Methods and results Consecutive patients with AL and ATTR‐CA diagnosed at participating...

article

Prevalence and predictors of bradyarrhythmias requiring permanent pacing in patients with Anderson–Fabry disease

Luigi Tassetti, Carlo Fumagalli, Alessia Argirò, Mattia Zampieri, more

Journal of Cardiovascular Electrophysiology > 33 > 5 > 1072 - 1078

Introduction Bradyarrhythmias are an established red flag for storage cardiac conditions including Anderson–Fabry disease (AFD). The prevalence of bradyarrhythmias requiring a pacemaker (PM) and their timing in AFD is unresolved. Methods We evaluated the prevalence and predictors of PM requirement in a large AFD cohort, investigating the occurrence of bradyarrhythmias as initial versus late manifestation...

article

Quality of life assessment in amyloid transthyretin (ATTR) amyloidosis

Alberto Aimo, Claudio Rapezzi, Federico Perfetto, Francesco Cappelli, more

European Journal of Clinical Investigation > 51 > 11 > n/a - n/a

Background Amyloid transthyretin (ATTR) amyloidosis is caused by the systemic deposition of transthyretin molecules, either normal (wild‐type ATTR, ATTRwt) or mutated (variant ATTR, ATTRv). ATTR amyloidosis is a disease with a severe impact on patients’ quality of life (QoL). Nonetheless, limited attention has been paid to QoL so far, and no specific tools for QoL assessment in ATTR amyloidosis currently...

article

Controlling and Phase‐Locking a THz Quantum Cascade Laser Frequency Comb by Small Optical Frequency Tuning

Luigi Consolino, Annamaria Campa, Michele De Regis, Francesco Cappelli, more

Laser & Photonics Reviews > 15 > 6 > n/a - n/a

Full phase control of terahertz (THz)‐emitting quantum cascade laser (QCL) combs has recently been demonstrated, opening new perspectives for even the most demanding applications. In this framework, simplifying the set‐ups for control of these devices will help to accelerate their spreading in many fields. This study reports a new way to control the emission frequencies of a THz QCL comb by small...

article

Quantum Cascade Lasers: Controlling and Phase‐Locking a THz Quantum Cascade Laser Frequency Comb by Small Optical Frequency Tuning (Laser Photonics Rev. 15(6)/2021)

Luigi Consolino, Annamaria Campa, Michele De Regis, Francesco Cappelli, more

Laser & Photonics Reviews > 15 > 6 > n/a - n/a

In article number 2000417, Luigi Consolino and co‐workers demonstrate a novel degree of freedom for controlling the emission of quantum cascade lasers (QCLs). It is based on small optical frequency tuning (SOFT) by means of a white LED. The slightly perturbative regime accessible in these conditions allows tweaking the semiconductor complex refractive index. The resulting additional tuning knob is...

article

Ventricular tachyarrhythmias and sudden cardiac death in light‐chain amyloidosis: a clash of cardio‐toxicities?

Mattia Zampieri, Marco Allinovi, Iacopo Olivotto, Elisabetta Antonioli, more

British Journal of Haematology > 193 > 4 > e27 - e31

article

Real‐world versus trial patients with transthyretin amyloid cardiomyopathy

Marco Canepa, Giacomo Tini, Beatrice Musumeci, Francesco Cappelli, more

European Journal of Heart Failure > 21 > 11 > 1479 - 1481

article

Cardiac Amyloidosis: Updates in Imaging

Liza Chacko, Raffaele Martone, Francesco Cappelli, Marianna Fontana

Current Cardiology Reports > 2019 > 21 > 9 > 1-9

Purpose of Review We summarize key features pertaining to the two most commonly encountered types of cardiac amyloidosis (CA), monoclonal immunoglobulin light chain (AL) and transthyretin type (ATTR), expanding upon the clinical application and utility of various imaging techniques in diagnosing CA. Recent Findings Advances in imaging have led to earlier identification, improved diagnosis of CA...

article

High-precision molecular spectroscopy in the mid-infrared using quantum cascade lasers

Simone Borri, Giacomo Insero, Gabriele Santambrogio, Davide Mazzotti, more

Applied Physics B > 2019 > 125 > 1 > 1-9

Quantum cascade lasers (QCLs) are becoming a key tool in several advanced experiments in the field of precision molecular spectroscopy and absolute frequency metrology. In view of this, a thorough control of their emission properties must be achieved, including a narrow linewidth as well as a high frequency-stability combined with referencing to a primary standard. Here, we give a review on recent...

article

Phenotypic profile of Ile68Leu transthyretin amyloidosis: an underdiagnosed cause of heart failure

Christian Gagliardi, Federico Perfetto, Massimiliano Lorenzini, Alessandra Ferlini, more

European Journal of Heart Failure > 20 > 10 > 1417 - 1425

Aims Cardiac amyloidosis remains a great challenge for the cardiologist. One of the three main aetiological forms, transthyretin‐related hereditary amyloidosis (ATTRm), can present with several phenotypes, depending mainly on the specific mutation. We aimed to characterize the phenotype of patients with ATTRm due to Ile68Leu mutation, comparing them to patients with wild‐type transthyretin amyloidosis...

article

Epigallocatechin-3-gallate tolerability and impact on survival in a cohort of patients with transthyretin-related cardiac amyloidosis. A single-center retrospective study

Francesco Cappelli, Raffaele Martone, Giulia Taborchi, Sofia Morini, more

Internal and Emergency Medicine > 2018 > 13 > 6 > 873-880

Transthyretin-related (ATTR) cardiac amyloidosis is currently lacking a disease-modifying therapy. Despite demonstration of effectiveness in halting amyloid deposition, no study focused on epigallocatechin-3-gallate (EGCG) impact on patient survival. We sought to explore prognostic impact of EGCG in a cohort of lone cardiac ATTR patients. From the Florence Tuscan Regional Amyloid Centre database,...

article

Lung uptake during 99mTc-hydroxymethylene diphosphonate scintigraphy in patient with TTR cardiac amyloidosis: An underestimated phenomenon

Francesco Cappelli, Chiara Gallini, Egidio Natalino Costanzo, Francesca Tutino, more

International Journal of Cardiology > 2018 > 254 > C > 346-350

Full body scintigraphy using bone tracers plays an important role in defining the type of amyloidosis and in diagnosing the heart involvement (cardiac amyloidosis, CA). No study has been conducted to explore lung retention (LR) in CA and its correlation to heart retention (HR).We evaluated LR in patients undergoing 99mTc-HMDP scintigraphy during evaluation for suspected CA.We enrolled 93 suspected...

article

Cardiac Resynchronization Therapy for End-Stage Hypertrophic Cardiomyopathy

Francesco Cappelli, Sofia Morini, Paolo Pieragnoli, Mattia Targetti, more

Journal of the American College of Cardiology > 2018 > 71 > 4 > 464-466

chapter

Towards the full frequency stabilization of quantum cascade laser frequency combs

Francesco Cappelli, Giulio Campo, Iacopo Galli, Luigi Consolino, more

2017 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) > 1

2017 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)

Optical frequency combs (OFCs) generated by quantum cascade lasers (QCLs) have recently been proven in the mid infrared [1] and they have already been applied to spectroscopy in free-running operation [2]. It is clear however that for more demanding applications such as high-resolution and accuracy spectroscopy and metrology the performance obtained in free-running operation is not enough, since a...

chapter

Probing and controlling the comb features of a THz QCL

Luigi Consolino, Annamaria Campa, Francesco Cappelli, Pablo Cancio Pastor, more

2017 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) > 1

2017 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)

Single mode THz QCLs have already shown their huge potential for metrological grade THz spectroscopy [1, 2] while, on the contrary, continuous-wave multimode broadband operation has only recently been demonstrated [3]. These sources show a comb emission regime with up to 600 GHz spectral coverage. This kind of sources are very promising for metrological-grade applications, such as high precision spectroscopy,...

article

Accuracy of 99mTc-Hydroxymethylene diphosphonate scintigraphy for diagnosis of transthyretin cardiac amyloidosis

Francesco Cappelli, Chiara Gallini, Carlo Mario, Egidio Natalino Costanzo, more

Journal of Nuclear Cardiology > 2019 > 26 > 2 > 497-504

Background and Aim Either 99mTechnetium diphosphonate (Tc-DPD) or pyrophosphate (Tc-PYP) scintigraphy plays a relevant role in diagnosing transthyretin cardiac amyloidosis (CA), and labeled radiotracers have been extensively studied in diagnosing CA. Few studies have analyzed and validated 99mTc-Hydroxymethylene diphosphonate (Tc-HMDP). Our aim was to validate the diagnostic accuracy of Tc-HMDP total-body...

chapter

Measuring the frequency stability of a quantum cascade laser frequency comb

Francesco Cappelli, Giulio Campo, Iacopo Galli, Giovanni Giusfredi, more

2016 Conference on Lasers and Electro-Optics (CLEO) > 1 - 2

2016 Conference on Lasers and Electro-Optics (CLEO)

Optical frequency combs generated by quantum cascade lasers have recently been proven in the mid infrared. The first attempt of frequency stabilizing a quantum cascade laser comb against a metrological mid-infrared frequency comb through a single phase-locking chain is presented.

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INFONA - science communication portal

Search results for: Francesco Cappelli

Diagnostic pathways to wild‐type transthyretin amyloid cardiomyopathy: a multicentre network study

Terahertz Sources Based on Metrological‐Grade Frequency Combs

Unmasking the prevalence of amyloid cardiomyopathy in the real world: results from Phase 2 of the AC‐TIVE study, an Italian nationwide survey

Incidence and risk factors for pacemaker implantation in light‐chain and transthyretin cardiac amyloidosis

Prevalence and predictors of bradyarrhythmias requiring permanent pacing in patients with Anderson–Fabry disease

Quality of life assessment in amyloid transthyretin (ATTR) amyloidosis

Controlling and Phase‐Locking a THz Quantum Cascade Laser Frequency Comb by Small Optical Frequency Tuning

Quantum Cascade Lasers: Controlling and Phase‐Locking a THz Quantum Cascade Laser Frequency Comb by Small Optical Frequency Tuning (Laser Photonics Rev. 15(6)/2021)

Ventricular tachyarrhythmias and sudden cardiac death in light‐chain amyloidosis: a clash of cardio‐toxicities?

Real‐world versus trial patients with transthyretin amyloid cardiomyopathy

Cardiac Amyloidosis: Updates in Imaging

High-precision molecular spectroscopy in the mid-infrared using quantum cascade lasers

Phenotypic profile of Ile68Leu transthyretin amyloidosis: an underdiagnosed cause of heart failure

Epigallocatechin-3-gallate tolerability and impact on survival in a cohort of patients with transthyretin-related cardiac amyloidosis. A single-center retrospective study

Lung uptake during 99mTc-hydroxymethylene diphosphonate scintigraphy in patient with TTR cardiac amyloidosis: An underestimated phenomenon

Cardiac Resynchronization Therapy for End-Stage Hypertrophic Cardiomyopathy

Towards the full frequency stabilization of quantum cascade laser frequency combs

Probing and controlling the comb features of a THz QCL

Accuracy of 99mTc-Hydroxymethylene diphosphonate scintigraphy for diagnosis of transthyretin cardiac amyloidosis

Measuring the frequency stability of a quantum cascade laser frequency comb

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