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There is an increasing number of health products which fall under the definition of “nanomaterials” currently available in the marketplace in Canada. However, the safety assessment and risk management of these products pose challenges as the knowledge in the field is evolving. The objective of this paper is to highlight the present state of regulatory oversight for nanomaterial-based health products...
In 26 hr laboratory trials a dose of 1000 μg/kg microcystin-LR (MC-LR) caused 100% mortality in rainbow trout, while no mortality was observed at doses of 400 μg/kg or less. The liver to body mass ratio increased in fish exposed to the toxin which was likely due to water retention in the liver. In contrast to mammalian studies, hemorrhage of the liver was rare in fish. Exposure to MC-LR caused...
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