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Low plasma concentrations of active transforming growth factor β (TGF-β) are associated with coronary artery disease although the mechanism causing decreased active TGF-β is uncertain. Plasmin activates TGF-β and therefore increased plasminogen activator inhibitor-1 (PAI-1) may cause decreased active TGF-β concentrations. TGF-β is a hydrophobic protein and we hypothesized that post-prandial lipemia...
Many epidemiological studies have shown that increased plasma concentrations of cholesterol-containing lipoproteins are associated with ischaemic heart disease (IHD). Recently it has been shown that decreased plasma concentrations of transforming growth factor β (TGF β) are also associated with IHD. The aim of this study was to determine whether lipoprotein particles can modulate TGF β activity...