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One of the key challenges in osteochondral tissue engineering is to achieve mechanical properties in the engineered tissue that are equivalent to the native tissue. Detailed knowledge of the mechanotransduction pathways occuring in the native tissue is necessary before manipulation towards the aimed properties in the engineered tissue. Purinergic (ATP-mediated) signaling is proving to be one of the...
Misdiagnosis of epilepsy, even by experienced clinicians, can cause exposure of patients to medical procedures and treatments with potential complications. Moreover, diagnostic delays (for 7 to 10 years on average) impose economic burden at individual and population levels. In this paper, a seizure classification framework of epileptic and non-epileptic events from multi-channel EEG data is proposed...
Biomedical signals (BSs), which give information about the normal condition and also the inherent irregularities of our body, are expected to have non-stationary character due to the time-varying behavior of physiological systems. The Fourier transform and the short time Fourier transform are the widely used frequency and time-frequency analysis methods for extracting information from BSs with fixed...
One of the approaches that could be used for cancer treatment is electroporation. This is a relatively new technique and thus its effect on various cancer cell types should be analyzed in detail. In this paper numerical simulations are used, in order to model the behavior of cells after electroporation. Fitting procedure was used for estimation of the parameters of the computer model. This model enables...
The development of several biomedical ontologies and databases for structuring and categorizing knowledge in life sciences, and particularly the ones which refer to the functions and interactions of biomolecules, have contributed to the rapid inflation of the semantic information universe that describes cellular complexity, at different scales. Together with the ever-growing number of high-throughput...
Investigation of the motion of deformable particles immersed in fluid is clinically very relevant because it can help to improve treatment planning, diagnostics of disease, design of efficient terapeutical procedures, analysis of drug transport, etc. Experimental investigation of these phenomena is difficult and expensive and, therefore, numerical simulations can contribute to the acquisition of a...
3D heart registration has become an important issue in cardio-vascular diagnosis and treatment. This is mainly due to more accessible medical imaging technologies that can nowadays provide high precision imaging data at relatively lower cost. One of the important features of the heart that has recently drawn attention is epicardial fat (surrounds the heart), which according to some preliminary studies...
This paper will consider a framework for simulation of musculoskeletal system via mass-spring system as the target application. The framework uses a mass-spring systems to simulate the muscle fibres of each muscle and an additional triangle model to visually represent the surface of the muscles. This requires establishing some relationship between the two models so that when some nodes of the mass-spring...
In studies so far have been shown that clinical analysis of the gait parameters is extremely important for improving diagnostics and following illness or deficiencies of lower extremities, as well as for analyzing recuperation levels after therapy. Purpose of this paper is to analyze possibility of using easily affordable web cameras for recording knee movement. Recordings are made with web cam on...
In this study the authors present the method for determination of exposure dose on human head during computer tomography (CT) scanning procedure. The method is based on the use of the feed-forward neural network (FFNN) model to predict the exposure dose on human head. The neural network with Levenberg-Marquardt learning is constructed. The training data are obtained using the Monte Carlo method simulation...
Signals with time-varying frequency content are generally best represented in the time frequency (TF) domain, with the components instantaneous frequency laws being their key nonstationary features. There are a number of methods for TF distribution calculation (TFD), however, most of them add unwanted artifacts, making the TFD interpretation more difficult. In this paper, we use a compressive sensing...
Automatic detection of necrosis in histological images is an interesting problem of digital pathology that needs to be addressed. Determination of presence and extent of necrosis can provide useful information for disease diagnosis and prognosis, and the detected necrotic regions can also be excluded before analyzing the remaining living tissue. This paper describes a novel appearance-based method...
Alizarin is anthraquinone with moderate antioxidative capacity. In this work mechanisms of antioxidative activity of alizarin with hydroperoxy and methylperoxy radicals are investigated. All calculations are carried out using B3LYP-D2 method and 6–311+G(d, p) basis set. It is affirmed based on several parameters that hydroxyl group at position 2 is predominant for antiradical activity. PCET mechanism...
The main purpose of this study is to examine how flow field in aortic dissection is affected by its geometry and flow condition. Two models of DeBakey type I aortic dissection, which involves the entire aorta, were analyzed. Patient-specific geometries were reconstructed, based on Computed tomography (CT) scan images, in order to obtain 3D finite element meshes. Computational fluid dynamics (CFD),...
The most common type of heart disease that affects millions of people worldwide is coronary heart disease (coronary artery disease). It is caused by a narrowing or blocking of the arteries due to plaque which restricts blood flow, and reduces the amount of oxygen to the heart [1]. Several tools are used that aid physicians in the treatment of the disease. Angiogram, which represents an X-ray examination...
A three dimensional biomechanical model of the human knee joint was developed. The model was created from MRI scans and includes: bones, menisci, articular cartilage and relevant ligaments (posterior cruciate ligament, lateral collateral ligament and medial collateral ligament). The purpose of this study was to compare the stress distribution on the human knee joint in two situations. The first situation...
Smoothed Particle Hydrodynamics is meshless numerical method which is based on continuum mechanics approach, capable of analyzing stresses in both solids and fluids as well as stresses that are result of solid-fluid interaction, with very versatile applications, and yet it' is not sufficiently implemented in biomechanics due to difficulties of node grid generation from complex shape objects. This...
Advancement in Next Generation Sequencing (NGS) technology are associated with ever-increasing volume of genomic data every year. These genomic data are efficiently processed by empirical parallelism using High Performance Computing (HPC). The processed data can be used for genome-wide association studies, genetics, personalized medicine and many other areas. There are different kind of algorithms...
Histopathology imaging and gene expression profiling are two fundamental investigative techniques which allow the analysis of biological specimens from different perspectives. Given their apparent divergence in data representation, they are usually used separately, being connected only at the higher levels of data analysis. In this work we demonstrate how gene expression can be used directly for guiding...
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