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The reported study represents a nice example of how state-of-the-art molecular modeling techniques can be used to study complicated macromolecular complexes, whose structures have not yet been experimentally determined, and to validate these against the available experimental data. The proposed structure will facilitate future studies on the rational design of successful Aflatoxin B1 (AFB1) modulators...
The role of intraluminal thrombus (ILT) has special attention in these studies. One of the papers showed that asymmetrical intraluminal thrombus deposition (ATDI) has an important role in growth of the AAA. The aim of our study was to assess the asymmetrical thrombus deposition index in ruptured and symptomatic aneurysms. We collected data for 33 aneurysms, 21 (63.63%) asymptomatic and 12 (33.37%)...
This paper presents computer analysis of how geometry of reconstructed gastrointestinal tract can influence outcome of Billroth II gastric resection. We performed three-dimensional computer simulation in order to predict duodenal stump blowout. For creation of initial three dimensional FE models of preoperative gastroduodenal region we used data from Multi Slice Computer Tomography (MSCT). Using the...
Cochlea is a part of the inner ear and it has complex anatomy and function. The proper functioning of the cochlea includes the generation of a traveling wave along the basilar membrane, which leads to depolarization of hair cells in the Organ of Corti and subsequent auditory nerve excitation (mechanoelectrical transduction). To represent the behavior of the organ of Corti, electro-mechanical cochlea...
Comet assay or single-cell gel electrophoresis is a widely used method for DNA damage assessment. The results of the method can be scored under microscopic examination either with the naked eye or automated systems. In this study, we present a semi-automatic comet assay analysis tool that was developed in our laboratory. The results obtained with our tool were compared with that of fully automatic...
Density functional computations on a series of complex systems and processes are presented and discussed. In particular the following subject have been investigated: i) catalytic mechanism of carbonic anhydrase; ii) structural properties of silver mediated DNA dimers; iii) structural and spectroscopic features of Zn-phthalocyanine derivatives; iv) carnosine-carboplatin, carnosine-oxaliplatin complexes...
The finite element method is increasingly used in the analysis of blood flow through blood vessels. Our work represents the research of blood flow through a cerebral aneurysm. The current work describes the blood flow in 4 patient-specific models of saccular aneurysms. They are located in the region of the anterior and posterior circulation of the circle of Willis. The unstructed grids are constructed...
In this study the authors present the method for determination of exposure dose on human head during computer tomography (CT) scanning procedure. The method is based on the use of the feed-forward neural network (FFNN) model to predict the exposure dose on human head. The neural network with Levenberg-Marquardt learning is constructed. The training data are obtained using the Monte Carlo method simulation...
Signals with time-varying frequency content are generally best represented in the time frequency (TF) domain, with the components instantaneous frequency laws being their key nonstationary features. There are a number of methods for TF distribution calculation (TFD), however, most of them add unwanted artifacts, making the TFD interpretation more difficult. In this paper, we use a compressive sensing...
The most common type of heart disease that affects millions of people worldwide is coronary heart disease (coronary artery disease). It is caused by a narrowing or blocking of the arteries due to plaque which restricts blood flow, and reduces the amount of oxygen to the heart [1]. Several tools are used that aid physicians in the treatment of the disease. Angiogram, which represents an X-ray examination...
A three dimensional biomechanical model of the human knee joint was developed. The model was created from MRI scans and includes: bones, menisci, articular cartilage and relevant ligaments (posterior cruciate ligament, lateral collateral ligament and medial collateral ligament). The purpose of this study was to compare the stress distribution on the human knee joint in two situations. The first situation...
Smoothed Particle Hydrodynamics is meshless numerical method which is based on continuum mechanics approach, capable of analyzing stresses in both solids and fluids as well as stresses that are result of solid-fluid interaction, with very versatile applications, and yet it' is not sufficiently implemented in biomechanics due to difficulties of node grid generation from complex shape objects. This...
The cell wall of Gram-negative bacteria plays a crucial role in the bacteria resistance to certain antimicrobials and its adaptation to the host environment. The first line of cell defense is its outer membrane composed of glycerophos-pholipids in the inner monolayer, lipopolysaccharides (LPS) in the outer monolayer and integral proteins. To understand the details of the outer membrane structure we...
An unsupervised methodology for the detection of Epileptic seizures in EEG recordings is proposed. The time-frequency content of the EEG signals is extracted using the Short Time Fourier Transform. The analysis focuses on the EEG energy distribution among the well-established delta, theta and alpha rhythms (2–13 Hz), as energy variations in these frequency bands are widely associated with seizure...
Human hearing system in general, and particularly the cochlea, is very interesting for investigation. The most important reason for it is hearing loss — a health problem that affects a large part of the world's human population. The highest percentage of people with hearing problems are older people, but the problem also occurs in newborns. Experimental research in this area provides some information...
In this article we present a fusion architecture for the automatic classification of sleep stages. The architecture relies on time and frequency domain features which are processed by dissimilar classifiers. The initial predictions of each classifier are refined by using fusion of the prediction estimations together with temporal contextual information of the electroencephalographic signal. The experimental...
Recently, there is an increasing motivation to develop telemonitoring systems that enable cost-effective screening of Parkinson's Disease (PD) patients. These systems are generally based on measuring the motor system disorders seen in PD patients by the help of non-invasive data collection tools. Vocal impairments one of the most commonly seen PD symptoms in the early stages of the disease, and building...
Gene expression data are widely used in classification tasks for medical diagnosis. Data scaling is recommended and helpful for learning the classification models. In this study, we propose a data scaling algorithm to transform the data uniformly to an appropriate interval by learning a generalized logistic function to fit the empirical cumulative density function of the data. The proposed algorithm...
In external beam radiotherapy (EBRT), one of the major challenges is to compensate for target motion induced by patient's respiration and organ motion. The accurate delivery of radiation to the moving targets (tumors) requires new innovative technologies and methods to avoid excessive irradiation of healthy tissue. Recently, we developed a tracking method for target motion compensations, which includes...
Computational methods such as clustering, classification and regression methods can be applied in immunoin-formatics to construct predictive models to reveal relationships between antibody features and their functional outcomes. This paper studies the effect of antibody features and the functional outcome obtained on RV144 vaccine recipients. The RV144 vaccine data set contains 100 data samples in...
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