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This paper reports a wrist-brace type sandwich structured triboelectric microgenerator (S-TEMG) by optimizing the effective surface area per unit volume for harvesting biomechanical energy from double human skins contact. The working mechanism of proposed harvester is based on the charge transfer between the Au electrode on Polydimethylsiloxane (PDMS) and ground via modulating the separation distance...
In many areas of the life sciences it is becoming increasingly important to analyze living cells individually in order to explore the significance of cell heterogeneity, the phenotypic differences between genetically identical cells and the influence of variations in the cell cycle for cell biological studies. Therefore, different methods have been published to show tools to separate, sort and manipulate...
Here we present integrated Lab-on-a-Disc (LoaD) cartridges which are applied to the purification of nucleic acid using the silica bead based method. We utilize a novel combination of ‘event-triggered’ dissolvable film (DF) valving [1] and a centrifugo-pneumatic siphon valve (CPSV) [2] to permit timing of sample incubations, washes and DNA elution. We present two systems; one in with a conventional...
A combination of a microfluidic device with a light modulation system was developed to detect the oxygen consumption rate of a single developing Caenorhabditis elegans (C. elegans) via phase-based phosphorescence lifetime detection. The microfluidic device combines two components: PMMA microwells containing an oxygen-sensitive luminescent layer and a microfluidic module with pneumatically actuated...
This paper reports a minimally invasive in vivo electroporation method utilizing parylene-based flexible electrode, after a treatment of microneedle device, Dermalroller®.[1] Upon penetrating high-resistance stratum corneum, the sufficient hypodermic electric field can be established under low voltage condition. Benefiting from more uniform electric field under skin, good biocompatibility, and lower...
In this study, we developed a novel time-resolved fluorescence (TRF)-based immunosensing platform that consisted with the physically stable europium chelate-encapsulated silica nanoparticle and the simplified TRF analyzer. To verify the applicability of developed TRF immunosensing platform toward practical immunoassay, the sandwich immunosensing of cardiac troponin I (cTnI) was accomplished using...
This work deals with the development of electrochemical transducers for the analysis of the metabolic status of mitochondria isolated from leukemic cells. It proposes the use of ring nanoelectrodes (RNE) integrated into microwell arrays for the simultaneous monitoring of the oxygen (O2) consumption and the hydrogen peroxide (H2O2) production. The sensor enabled the real-time recording of the oxygen...
In this study, we developed a filter-free fluorescence image sensor that performed 2D fluorescence imaging without optical filters utilizing the wavelength-dependent absorption depth of a silicon substrate. This sensor changes the potential distribution in the depth direction of the silicon substrate by controlling a potential of the polysilicon gate atop the sensing area. And it can display both...
A mobile immunoassay system which carries out all its procedure on a CMOS chip is proposed. This method utilizes magnetic beads as its assay marker and provides a simplified protocol. The chip is fabricated in a 0.35 μm standard complementary metal-oxide-semiconductor (CMOS) process. Just one post processing, etch back Hall sensor area, enhances its sensitivity and an RF drain current across it lowers...
This paper reports the size-selective sampling and removal of airborne nanoparticles (NP) using a silicon resonant micro cantilever mass balance combined with a miniaturized electrostatic precipitator (ESP). This allows to design an overnight-refreshable, pocket-sized, autarkic monitor for NP mass concentration and size in the range below 300 nm.
This paper compares a MEMS-based resonant cantilever and an interdigitated capacitor, both coated with an amino-functionalized sensing film, as room temperature carbon dioxide (CO2) detectors. The sensor sensitivities at room temperature to CO2 are assessed as well as their cross-sensitivities to temperature and humidity. The effectiveness of an uncoated reference cantilever for temperature compensation...
This paper reported a miniaturized sensitive gravimetric gas sensor based on film bulk acoustic resonator (FBAR). The sensitivity of the FBAR gas sensor was enhanced 10∼20 times after coating with nanomaterials (metal organic frameworks (MOFs)). A facile coating process of MOFs on FBARs was disclosed for the first time. Furthermore, utilizing FBAR sensors as detectors was firstly demonstrated in a...
An integrated volatile organic compounds (VOC) sensor based on silicon photonic ring resonator system is presented in this paper. A thin absorption layer is coated on the silicon surface required to selectively trap the target gas and response as refractive index change. This acts as the main sensing unit, which subsequently affect the resonance peak position. The relative high sensitivity (1.7 pm/...
Herein, we present a self-powered active hydrogen (H2) sensor using a corrugated-core sandwich-structured triboelectric nanogenerator (CS-TENG). The working capability of the sensor can be tuned by varying the corrugated sheet's orientation in the sandwich plates and/or stacking two single-unit TENGs in parallel. The sensor offers superior sensing properties (responsemax: 79%; detection: 0.001–1 vol%)...
In this paper we report of a novel and very simple fabrication method for realizing amperometric gas sensors using conventional wire bonding technology. Working and counter electrodes are made of 360 vertically standing bond wires, entirely manufactured by a fully automated, standard wire bonding tool. Our process enables standing bond wires with a length of 1.24 mm, resulting in an extremely high...
This paper reports a novel top-down and bottom-up compatible technique for sensing materials self-aligned upload onto the specific area of sensor. Using a lift-off-like fabrication process, hydrophobic self-assembly monolayer (SAM) is patterned on the non-sensing area of suspended heating-plate while the surface of sensing area is kept hydrophilic by chrome layer. Constrained by hydrophobic surface,...
This paper presents a novel paper-based microfluidic cassette for 2D paper chromatography and electrospray ionization (ESI) for rapid mass spectrometry screening of pesticides in vegetable. Instead of using conventional bulky HPLC/MS systems, liquid sample is directly applied on the cassette for sample separation with paper chromatography and then enriched with the second paper chromatography for...
We present the theoretical analysis of a three coupled resonator array without any mass perturbation and simulated results of its vibration behaviors under different exciting conditions. It can be concluded that the exciting condition mainly affects the sensing resonator's amplitude value instead of mode shape. Additionally, considering little influence on the mode shape caused by different exciting...
This study reports hydrogen sensors based on ultra-small bimetallic palladium/magnesium (Pd/Mg) nanowires network on commercial filtration membrane. Previously, hydrogen sensors based on single Pd nanowires showed promising results in speed, sensitivity, and ultra-low power consumption. However, the utilization of single Pd nanowires faces challenges in nanofabrication, manipulation, and achieving...
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