Search results for: T. C. Pearson

Items from 1 to 11 out of 11 results

article

Belatacept Combined With Transient Calcineurin Inhibitor Therapy Prevents Rejection and Promotes Improved Long‐Term Renal Allograft Function

A. B. Adams, J. Goldstein, C. Garrett, R. Zhang, more

American Journal of Transplantation > 17 > 11 > 2922 - 2936

Belatacept, a T cell costimulation blocker, demonstrated superior renal function, lower cardiovascular risk, and improved graft and patient survival in renal transplant recipients. Despite the potential benefits, adoption of belatacept has been limited in part due to concerns regarding higher rates and grades of acute rejection in clinical trials. Since July 2011, we have utilized belatacept‐based...

article

Fc‐Silent Anti‐CD154 Domain Antibody Effectively Prevents Nonhuman Primate Renal Allograft Rejection

S. C. Kim, W. Wakwe, L. B. Higginbotham, D. V. Mathews, more

American Journal of Transplantation > 17 > 5 > 1182 - 1192

The advent of costimulation blockade provides the prospect for targeted therapy with improved graft survival in transplant patients. Perhaps the most effective costimulation blockade in experimental models is the use of reagents to block the CD40/CD154 pathway. Unfortunately, successful clinical translation of anti‐CD154 therapy has not been achieved. In an attempt to develop an agent that is as effective...

article

Renal Transplantation Using Belatacept Without Maintenance Steroids or Calcineurin Inhibitors

A. D. Kirk, A. Guasch, H. Xu, J. Cheeseman, more

American Journal of Transplantation > 14 > 5 > 1142 - 1151

Kidney transplantation remains limited by toxicities of calcineurin inhibitors (CNIs) and steroids. Belatacept is a less toxic CNI alternative, but existing regimens rely on steroids and have higher rejection rates. Experimentally, donor bone marrow and sirolimus promote belatacept's efficacy. To investigate a belatacept‐based regimen without CNIs or steroids, we transplanted recipients of live donor...

article

Racial Disparities in Kidney Graft Survival: Does Donor Quality Explain the Difference?

R. E. Patzer, T. C. Pearson

American Journal of Transplantation > 12 > 7 > 1670 - 1671

article

CTLA4Ig Prevents Alloantibody Formation Following Nonhuman Primate Islet Transplantation Using the CD40‐Specific Antibody 3A8

I. R. Badell, M. C. Russell, K. Cardona, V. O. Shaffer, more

American Journal of Transplantation > 12 > 7 > 1918 - 1923

Islet transplantation to treat type 1 diabetes has been limited in part by toxicities of current immunosuppression and recipient humoral sensitization. Blockade of the CD28/CD80/86 and CD40/CD154 pathways has shown promise to remedy both these limitations, but translation has been hampered by difficulties in translating CD154‐directed therapies. Prior CD40‐directed regimens have led to prolonged islet survival, but fail to prevent humoral allosensitization. We therefore evaluated the addition of CTLA4Ig to a CD40 blockade‐based regimen in nonhuman primate (NHP) alloislet transplantation. Diabetic rhesus macaques were transplanted allogeneic islets using the CD40‐specific antibody 3A8, basiliximab induction, and sirolimus with or without CTLA4Ig maintenance therapy. Allograft survival was determined by fasting blood glucose levels and flow cytometric techniques were used to test for donor‐specific antibody (DSA) formation. CTLA4Ig plus 3A8, basiliximab and sirolimus was well tolerated and induced long‐term islet allograft survival. The addition of CTLA4Ig prevented DSA formation, but did not facilitate withdrawal of the 3A8‐based regimen. Thus, CTLA4Ig combines with a CD40‐specific regimen to prevent DSA formation in NHPs, and offers a potentially translatable calcineurin inhibitor‐free protocol inclusive of a single investigational agent for use in clinical islet transplantation without relying upon CD154 blockade.

article

Miles to Go…

A. D. Kirk, S. J. Knechtle, C. P. Larsen, K. A. Newell, more

American Journal of Transplantation > 11 > 6 > 1119 - 1120

article

Donor‐Directed MHC Class I Antibody Is Preferentially Cleared from Sensitized Recipients of Combined Liver/Kidney Transplants

W. Dar, A. Agarwal, C. Watkins, H. M. Gebel, more

American Journal of Transplantation > 11 > 4 > 841 - 847

For patients with chronic renal and liver diseases, simultaneous liver and kidney transplantation (SLKT) is the best therapeutic option. The role of a pretransplant donor‐specific antibody (DSA) in SLKT is unclear. We report the results of a retrospective review from 7/08 to 10/09 of SLKT at our institution. Monitoring of DSA was performed using single antigen bead assay. Between 7/08 and 10/09, there were six SLKT who had preformed DSA and positive XM (four class I and II DSA, one class I DSA only, one class II only). One‐year patient and renal graft survival was 83%. Death‐censored liver allograft survival was 100%. Acute humoral rejection (AHR) of the kidney occurred in 66% (three with both class I and II DSA and one with only class II DSA) of patients. In those with AHR, class I antibodies were rapidly cleared (p < 0.01) while class II antibodies persisted (p = 0.25). All patients who had humoral rejection of their kidney had preformed anticlass II antibodies. Liver allografts may not be fully protective of the renal allograft, especially with pre‐existing MHC class II DSA. Long‐term and careful follow‐up will be critical to determine the impact of DSA on both allografts....

article

Experience with a Novel Efalizumab‐Based Immunosuppressive Regimen to Facilitate Single Donor Islet Cell Transplantation

N. A. Turgeon, J. G. Avila, J. A. Cano, J. J. Hutchinson, more

American Journal of Transplantation > 10 > 9 > 2082 - 2091

Islet transplantation is an experimental therapy for selected patients with type 1 diabetes (T1DM). It remains limited by immunosuppressive drug toxicity, progressive loss of insulin independence, allosensitization and the need for multiple islet donors. We describe our experience with an efalizumab‐based immunosuppressive regimen as compared to the prevailing standard regimen, the Edmonton protocol. Twelve patients with T1DM received islet transplants: eight were treated with the Edmonton protocol; four were treated with daclizumab induction, a 6‐month course of tacrolimus, and maintenance with efalizumab and mycophenolate mofetil. The primary endpoint was insulin independence after one islet infusion. Only two Edmonton protocol treated patients achieved the primary endpoint; six required islets from multiple donors, and all experienced leukopenia, mouth ulcers, anemia, diarrhea and hypertransaminasemia. Four became allosensitized. All patients treated with the efalizumab‐based regimen achieved insulin independence with normal hemoglobin A1c after a single islet cell infusion and remained insulin independent while on efalizumab. These patients experienced significantly fewer side effects and none became allosensitized. Trial continuation was terminated by withdrawal of efalizumab from the market. These data suggest that this efalizumab‐based regimen prevents islet rejection, is well tolerated, and allows for single donor islet transplantation....

article

Separating in-shell pistachio nuts from kernels using impact vibration analysis

Ron P. Haff, T. C. Pearson

Journal of Food Measurement and Characterization > 2007 > 1 > 4 > 188-192

A sorting system has been developed for the separation of small in-shell pistachio nuts from kernels without shells on the basis of vibrations generated when moving samples strike a steel plate. Impacts between the steel plate and the hard shells, as measured using an accelerometer attached to the bottom of the plate, produce higher frequency signals than impacts between the plate and the kernels...

article

An automatic algorithm for detection of infestations in X-ray images of agricultural products

R. P. Haff, T. C. Pearson

Journal of Food Measurement and Characterization > 2007 > 1 > 3 > 143-150

An automatic recognition algorithm was developed and tested for detection of certain defects or contaminants in X-ray images of agricultural commodities. Testing of the algorithm on wheat kernels infested with larvae of the granary weevil, Sitophilus granarius (L.) yielded comparable results to those obtained by human subjects evaluating digitized X-ray film images (14.4% overall error vs. 15.6% for...

article

Polycythemia

M. Messinezy, T. C. Pearson

Molecular Aspects of Medicine > 1996 > 17 > 2 > 189-207

Plethora ( a morbid condition due to excess of red corpuscles ) has been recognized since antiquity as a manifestation of disease. The use of leeches and blood letting, which was for centuries the mainstay of therapy in many clinical situations, reflected the importance then attached to having too much blood. Greater knowledge has achieved greater precision, so that measurement of packed cell...

Filter options

Publication date

Set your own date range

INFONA - science communication portal

Search results for: T. C. Pearson

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options