Molecular Aspects of Medicine

Items from 1 to 20 out of 743 results

article

P-Glycoprotein-Mediated Multidrug Resistance in Tumor Cells: Biochemistry, Clinical Relevance and Modulation

Chaim Shustik, William Dalton, Philippe Gros

Molecular Aspects of Medicine > 1995 > 16 > 1 > 1-78

article

Self and Non-Self Antigen in Diabetic Autoimmunity: Molecules and Mechanisms

Wolfram J. P. Karges, Jorma Ilonen, Brian H. Robinson, Hans-Michael Dosch

Molecular Aspects of Medicine > 1995 > 16 > 2 > 79-213

In this article, we have summarized current facts, models and views of the autoimmunity that leads to destruction of insulin-producing β-cells and consequent Type 1 (insulin-dependent) diabetes mellitus. The presence of strong susceptibility and resistance gene loci distinguishes this condition from other autoimmune disorders, but environmental disease factors must conspire to produce disease. The...

article

Proteinase Inhibitors from the European Medicinal Leech Hirudo medicinalis: Structural, Functional and Biomedical Aspects

Paolo Ascenzi, Gino Amiconi, Wolfram Bode, Martino Bolognesi, more

Molecular Aspects of Medicine > 1995 > 16 > 3 > 215-313

article

DNA Technology in Forensic Applications

Manfred N. Hochmeister

Molecular Aspects of Medicine > 1995 > 16 > 4 > 315-437

article

Ageing--A biological perspective

Suresh I. S. Rattan

Molecular Aspects of Medicine > 1995 > 16 > 5 > 439-508

article

Lipids and atherosclerosis

Manuel Júdice Halpern

Molecular Aspects of Medicine > 1995 > 16 > 6 > 509-710

article

Apoptosis -- molecular mechanisms and biomedical implications

David J. McConkey, Boris Zhivotovsky, Sten Orrenius

Molecular Aspects of Medicine > 1996 > 17 > 1 > 1-110

Apoptosis is a distinct form of cell death of importance in tissue development and homeosasis and in several diseases. This review summarizes current knowledge about the regulation and molecular mechanisms of apoptosis and discusses the potential role of disregulated apoptosis in several major diseases. Finally, we speculate that modulation of apoptosis may be a target in future drug therapy.

article

Red Cell Physiology

Donatella Bossi, Bruno Giardina

Molecular Aspects of Medicine > 1996 > 17 > 2 > 117-128

The erythrocyte, the ultimate product of mammalian erythroid maturation, appears as a highly specialized and, paradoxically, a very simplified cell. In fact it lacks a nucleus and the intracellular organelles are essentially designed to transport oxygen from the outer environment to respiring tissues through the sophisticated functional properties of intraerythrocytic hemoglobin. In this respect,...

article

Hemolytic Anemias Due to Hemoglobinopathies

Claude Poyart, Henri Wajcman

Molecular Aspects of Medicine > 1996 > 17 > 2 > 129-142

Hemoglobinopathies responsible for hemolytic anemias may be divided into two groups. The first one corresponds to thalassemias and the second to the presence of a structurally abnormal hemoglobin (Hb).In thalassemia, the primary biochemical abnormality is a quantitative defect in the biosynthesis of one type of Hb chain. This defect leads to an overall deficit of Hb accumulation in the erythrocyte...

article

Hemolytic Anemias Due to Disorders of Red Cell Membrane Skeleton

Donatella Bossi, Matteo Russo

Molecular Aspects of Medicine > 1996 > 17 > 2 > 171-188

During the past 10 years, knowledge of the composition, function and supramolecular assembly of the red cell membrane has been greatly expanded by progress in molecular and cell biology. Detailed information on the organization of membrane cytoskeletal proteins and their molecular characterization has allowed us to correlate a number of protein abnormalities with clinical symptoms that are peculiar...

article

Polycythemia

M. Messinezy, T. C. Pearson

Molecular Aspects of Medicine > 1996 > 17 > 2 > 189-207

Plethora ( a morbid condition due to excess of red corpuscles ) has been recognized since antiquity as a manifestation of disease. The use of leeches and blood letting, which was for centuries the mainstay of therapy in many clinical situations, reflected the importance then attached to having too much blood. Greater knowledge has achieved greater precision, so that measurement of packed cell...

article

Hemolytic Anemias Due to Erythrocyte Enzyme Deficiencies

Gisela Jacobasch, Samuel M. Rapoport

Molecular Aspects of Medicine > 1996 > 17 > 2 > 143-170

Red blood cells can only fulfil their functions over the normal period of approximately 120 days with 1.7 10 ⁵ circulatory cycles efficiently if they withstand external and internal loads. This requires ATP and redox equivalents, which have to be permanently regenerated by the energy and redox metabolism. These pathways are necessary to maintain the biconcave shape of the cells, their...